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Some of these games come with bonus rounds that allow players to win free spins. Gates of Olympus, a new release by the company, transports players into the world of the ancient Greek gods where Zeus oversees all the action. The high-risk slot game features a Pay Anywhere option that rewards players if they get 8 or more identical symbols on the reels. It also has a lucrative Free Spins feature with multipliers that can be as high as 500x bet. Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from various geographical areas. This kind of heterogeneity is required for pragmatic trials to be valid, and it also helps reduce the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial. Pragmatic Play, a major player on the live casino market, provides an array of traditional table games, including Blackjack and Roulette. 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Some Pragmatic Play websites even let you test your luck on the move by playing a test mode. This will allow you to get familiar with the game's rules and features before playing with real money. Legality Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. Its software is accessible on mobile devices and in a variety of languages. It has been recognized as one of the leading casino gaming platforms despite its relative youth. Wolves is one of the latest games that is a 5-reel slot machine with a hefty RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat. The purpose of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually requested by policy makers and practitioners to guide their decision-making. They also provide a useful method of determining the causality between an intervention and its outcomes. However, they shouldn't be used to substitute for explanatory trials. The concept of pragmatism is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study, including recruitment, design, delivery of the intervention and its follow-up. There is a positive increase in the number pragmatic trials that have been published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, which are shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatism. It is important to keep in mind, however, that the majority were conducted in primary care settings.